Author

Y. Yarden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Noronha· 2 shared R. Will· 2 shared S. Wiemann· 2 shared A. H. C. van Kampen· 1 shared A. Tennenhouse· 1 shared A. Wachter· 1 shared C. Giacomelli· 1 shared C. Körner· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBioengineering

A. Noronha

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Reliable energy-based antibody humanization and stabilization

A. Tennenhouse, L. Khmelnitsky, R. Khalaila, N. Yeshaya, A. Noronha, M. Lindzen, E. Makowski, I. Zaretsky, Y. Fridmann Sirkis, Y. Galon-Wolfenson, P. M. Tessier, J. Abramson, Y. Yarden, D. Fass, S. J. Fleishman

The paper introduces CUMAb, a computational method for humanizing antibodies that improves stability and binding by systematically grafting CDRs onto human frameworks and ranking designs using Rosetta simulations.

bioRxiv · Aug 14, 2022Bioengineering

Coordinated regulation of WNT/β-catenin, c-Met, and Integrin signalling pathways by miR-193b controls triple negative breast cancer metastatic traits

C. Giacomelli, J. Jung, A. Wachter, S. Ibing, R. Will, H. Mannsperger, S. Uhlmann, O. Sahin, Y. Yarden, T. Beissbarth, U. Korf, C. Körner, S. Wiemann

This study identifies miR-193b as a key regulator of WNT/β-catenin, c-Met, and integrin pathways in TNBC, showing its strong repressive effect on metastatic traits.

bioRxiv · May 10, 2021Cancer Biology

Time-resolved profiling reveals ATF3 as a novel mediator of endocrine resistance in breast cancer

S. Borgoni, E. Sofyali, M. Soleimani Dodaran, H. Wilhelm, K. Mueller-Decker, R. Will, A. Noronha, P. J. Verschure, Y. Yarden, L. Magnani, A. H. C. van Kampen, P. D. Moerland, S. Wiemann

This study identifies ATF3 as a novel mediator of endocrine resistance in breast cancer through time-resolved profiling and validates its role in key signaling pathways and clinical relevance.

bioRxiv · Jun 8, 2020Cancer Biology