Use of phase plate cryo-EM reveals conformation diversity of therapeutic IgG with 50 kDa Fab fragment resolved below 6 angstrom
H. H. Lin, C.-H. Wang, Y.-M. Wu, S.-H. Huang, S. S.-Y. Lin, T. Kato, K. Namba, N. Hosogi, C. Song, K. Murata, C.-H. Yen, T.-L. Hsu, C.-H. Wong, I.-P. Tu, W.-H. Chang
This study uses phase plate cryo-EM to reveal conformational diversity in therapeutic IgG, achieving sub-nanometer resolution of the Fab fragment.
Scientific Reports · Jun 18, 2024Peer-reviewedBiochemistry