Author

Y.-M. Wu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 2 Organism:mouse· 2 Research Focus:protein structure prediction· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C.-H. Wong· 2 shared A. J. Todd· 1 shared A. M. Chinnaiyan· 1 shared A. Parolia· 1 shared C. Cheng· 1 shared C. J. Lord· 1 shared C. Ma· 1 shared C. Song· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

C.-H. Wong

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Use of phase plate cryo-EM reveals conformation diversity of therapeutic IgG with 50 kDa Fab fragment resolved below 6 angstrom

H. H. Lin, C.-H. Wang, Y.-M. Wu, S.-H. Huang, S. S.-Y. Lin, T. Kato, K. Namba, N. Hosogi, C. Song, K. Murata, C.-H. Yen, T.-L. Hsu, C.-H. Wong, I.-P. Tu, W.-H. Chang

This study uses phase plate cryo-EM to reveal conformational diversity in therapeutic IgG, achieving sub-nanometer resolution of the Fab fragment.

Scientific Reports · Jun 18, 2024Peer-reviewedBiochemistry

CDK12 Loss Promotes Prostate Cancer Development While Exposing Vulnerabilities to Paralog-Based Synthetic Lethality

J. C.-Y. Tien, Y. Chang, Y. Zhang, J. Chou, Y. Cheng, X. Wang, J. Yang, R. Mannan, P. Shah, X.-M. Wang, A. J. Todd, S. Eyunni, C. Cheng, R. J. Rebernick, L. Xiao, , A. M. Chinnaiyan

This study shows CDK12 loss drives prostate cancer development and identifies CDK13 as a therapeutic target through paralog-based synthetic lethality in CDK12-mutant tumors.

bioRxiv · Mar 20, 2024Cancer Biology

Cryo-EM reveals the structure and dynamics of a 723-residue malate synthase G

M.-R. Ho, Y.-M. Wu, Y.-C. Lu, T.-P. Ko, K.-P. Wu

The paper presents a 2.9-Å cryo-EM structure of malate synthase G from E. coli, showing it matches crystallographic and NMR structures and reveals conformational dynamics.

bioRxiv · Aug 19, 2022Biophysics

Impact of glycosylation on a broad-spectrum vaccine against SARS-CoV-2

H.-Y. Huang, H.-Y. Liao, X. Chen, S.-W. Wang, C.-W. Cheng, M. Shahed-Al-Mahmud, T.-H. Chen, J. M. Lo, Y.-M. Liu, Y.-M. Wu, H.-H. Ma, Y.-H. Chang, H.-Y. Tsai, Y.-C. Chou, Y.-P. Hsueh, , C.-H. Wong

This study shows that trimming N-glycans from the SARS-CoV-2 spike protein enhances immune responses and protection against variants in hACE2 mice.

bioRxiv · May 25, 2021 · PreprintMicrobiology