Author

C.-H. Wong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

S.-W. Wang· 2 shared Y.-M. Wu· 2 shared C. Ma· 1 shared C. Song· 1 shared C.-H. Wang· 1 shared C.-H. Yen· 1 shared C.-W. Cheng· 1 shared C.-Y. Chen· 1 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersBiochemistry

S.-W. Wang

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Use of phase plate cryo-EM reveals conformation diversity of therapeutic IgG with 50 kDa Fab fragment resolved below 6 angstrom

H. H. Lin, C.-H. Wang, Y.-M. Wu, S.-H. Huang, S. S.-Y. Lin, T. Kato, K. Namba, N. Hosogi, C. Song, K. Murata, C.-H. Yen, T.-L. Hsu, C.-H. Wong, I.-P. Tu, W.-H. Chang

This study uses phase plate cryo-EM to reveal conformational diversity in therapeutic IgG, achieving sub-nanometer resolution of the Fab fragment.

Scientific Reports · Jun 18, 2024Peer-reviewedBiochemistry

Synthesis and Assembly of a New-generation Bifunctional Lipid Nanoparticle for Selective Delivery of mRNA to Antigen Presenting Cells

C.-Y. Chen, S.-W. Wang, C.-H. Wong

This paper develops a new mRNA-BLNP3 nanoparticle that selectively delivers mRNA to antigen-presenting cells, showing improved immune responses and reduced liver accumulation compared to previous versions.

bioRxiv · Dec 26, 2023 · PreprintBiochemistry

Cell-based production of Fc-GlcNAc and Fc-alpha-2,6 sialyl glycan enriched antibody with improved effector functions through glycosylation pathway engineering

H.-W. Huang, C.-H. Wong, V. S. Shivatare, T.-H. Tseng

This study develops two methods to produce antibodies with homogeneous Fc-SCT glycans, improving effector functions through glycosylation pathway engineering in cell lines.

bioRxiv · Dec 18, 2023 · PreprintBiochemistry

Synthesis of Dendritic Cell-Targeted Polymeric Nanoparticles for Selective Delivery of mRNA Vaccines to Elicit Enhanced Immune Responses

This paper develops DC-targeted polymeric nanoparticles for mRNA vaccine delivery, showing enhanced immune responses in mice compared to traditional LNPs.

bioRxiv · Nov 13, 2023 · PreprintBiochemistry

Impact of glycosylation on a broad-spectrum vaccine against SARS-CoV-2

H.-Y. Huang, H.-Y. Liao, X. Chen, S.-W. Wang, C.-W. Cheng, M. Shahed-Al-Mahmud, T.-H. Chen, J. M. Lo, Y.-M. Liu, Y.-M. Wu, H.-H. Ma, Y.-H. Chang, H.-Y. Tsai, Y.-C. Chou, Y.-P. Hsueh, , C.-H. Wong

This study shows that trimming N-glycans from the SARS-CoV-2 spike protein enhances immune responses and protection against variants in hACE2 mice.

bioRxiv · May 25, 2021 · PreprintMicrobiology