C. Song

Coronavirus Nucleocapsid Protein Enhances the binding of p-PKCα to RACK1: Implications for Inhibition of Nucleocytoplasmic Trafficking and Suppression of the Innate Immune Response

This study identifies how the coronavirus N protein disrupts nucleocytoplasmic trafficking and suppresses the innate immune response by promoting RACK1-PKC interaction and NUP62 phosphorylation.

Use of phase plate cryo-EM reveals conformation diversity of therapeutic IgG with 50 kDa Fab fragment resolved below 6 angstrom

This study uses phase plate cryo-EM to reveal conformational diversity in therapeutic IgG, achieving sub-nanometer resolution of the Fab fragment.

Predicting the alternative conformation of a known protein structure based on the distance map of AlphaFold2

This study shows that AlphaFold2 distance maps can reveal multi-state protein structures, enabling prediction of alternative conformations with high accuracy.

Negative regulation of APC/C activation by MAPK-mediated attenuation of Cdc20Slp1 under stress

The paper shows that MAPK Pmk1 in fission yeast inhibits APC/C activation by phosphorylating and degrading Slp1Cdc20 under stress, revealing a conserved regulatory mechanism.

Sec23IP recruits the Cohen syndrome factor VPS13B/COH1 to ER exit site-Golgiinterface for tubular ERGIC formation

This study identifies Sec23IP as a VPS13B adaptor that recruits VPS13B to ER exit sites-Golgi interfaces, promoting tubular ERGIC formation and affecting procollagen export, linking it to Cohen syndrome pathogenesis.

Switching Go-Martini for Investigating Protein Conformational Transitions and Associated Protein-Lipid Interactions

The paper introduces a new method, Switching G[o]-Martini, to simulate protein conformational transitions and protein-lipid interactions, validated on multiple protein systems.

GreenGate 2.0: backwards compatible addons for assembly of complex transcriptional units and their stacking with GreenGate

GreenGate 2.0 improves modular cloning by increasing module capacity, streamlining entry clone generation, and enabling efficient stacking of transcriptional units for complex genetic constructs.

Functional analysis of Cdc20 reveals a critical role of CRY box in mitotic checkpoint signaling

This study functionally analyzes Cdc20's role in mitotic checkpoint signaling by identifying the CRY box's critical role in SAC through MCC formation and APC/C interaction.

Strigolactones optimise plant water usage by modulating vessel formation

The paper identifies strigolactone signaling's role in modulating vessel element formation in Arabidopsis, enhancing drought resistance by altering water transport efficiency.

Coronavirus endoribonuclease nsp15 induces host cellular protein synthesis shutoff

This study shows that coronavirus nsp15 inhibits host protein synthesis and targets host mRNA, with EndoU activity essential for these effects and virus replication.

Structure and its transformation of elliptical nege-like virus Tanay virus

This study determines the cryo-EM structure of Tanay virus and reveals its dynamic shape changes under different conditions, suggesting structural roles in infection and assembly.

Osteoblast-intrinsic defect in glucose metabolism impairs bone formation in type II diabetic mice

This study shows that impaired glucose metabolism in osteoblasts causes reduced bone formation in type 2 diabetic mice, and identifies potential therapeutic targets.

Protein aggregation in plant mitochondria inhibits translation and induces an NAC017-dependent ethylene-associated unfolded protein response

Lon1 knockout inhibits mitochondrial-encoded gene translation and induces retrograde signaling involving unfolded protein responses.

Reconceptualizing beta diversity: a hypervolume geometric approach

This paper introduces a geometric hypervolume approach to measure beta diversity, accounting for non-additivity and species interactions, and applies it to address ecological questions.

The photosystem I supercomplex from a primordial green alga Ostreococcus tauri harbors three light-harvesting complex trimers

This paper reports the structure and function of the photosystem I supercomplex in Ostreococcus tauri, showing it assembles with light-harvesting complexes and exhibits reversible photoacclimation.

CRISPR/FnCas12a-mediated efficient multiplex and iterative genome editing in bacterial plant pathogens without donor DNA templates

This paper develops a CRISPR/Cas12a-based genome editing method for bacterial plant pathogens without donor DNA, enabling efficient gene knockout and multiplex editing in Xanthomonas oryzae pv. oryzae.

Spatial transcriptomic profiling of coronary endothelial cells in SARS-CoV-2 myocarditis

This study uses spatial transcriptomics to analyze SARS-CoV-2 infection in coronary endothelial and myocardial tissues from COVID-19 patients, finding unique pro-inflammatory profiles in capillaries but not larger vessels.

Calcium binding and permeation in TRPV channels: insights from molecular dynamics simulations

This study uses molecular dynamics simulations to compare Ca2+ permeation in TRPV6 and TRPV1 channels, revealing distinct ion-binding patterns and mechanisms of Ca2+ selectivity.

DBERlibR: Automated Data Analysis for Discipline-Based Education Research

DBERlibR automates data analysis for DBER by processing, cleaning, and applying statistical tests to assessment data, streamlining research workflows.

Complexes of tubulin oligomers and tau form an intervening network cross-bridging microtubules into bundles

The paper identifies an intervening network of tubulin-tau complexes that cross-link microtubules into bundles, revealing a new role for tubulin in stabilizing MT fascicles and preventing tau leakage in neurodegeneration.

Rapid monitoring for ecological persistence

The paper shows that persistence of small ecological subnetworks can reliably predict the persistence of entire ecological networks, aiding conservation efforts.

Exploring the alternative conformation of a known protein structure based on contact map prediction

This study shows that deep learning-based contact map predictions can capture structural information of multiple states, enabling exploration of alternative conformations of a known protein structure.

Separation of phosphatase and kinase activity within the Bub complex is required for proper mitosis

This study shows that separating kinase and phosphatase activities in the Bub complex is essential for proper mitosis, as merging these functions leads to mitotic defects.

Identification of Alkaloids and Related Intermediates of Dendrobium officinale by Solid-Phase Extraction Coupled with High-Performance Liquid Chromatography Tandem Mass Spectrometry

This study identifies alkaloids and related intermediates in Dendrobium officinale using SPE-HPLC-LTQ-Orbitrap and database alignment.

Toward Atomistic Models of Intact SARS-CoV-2 via Martini Coarse-Grained Molecular Dynamics Simulations

This study constructs multiscale models of SARS-CoV-2 using coarse-grained molecular dynamics simulations and experimental data, revealing dynamic behavior of membrane proteins and lipid interactions.

Characterization and identification of a novel daidzein reductase involved in (S)-equol biosynthesis in Clostridium C1

This paper identifies a novel daidzein reductase gene C1-07020 from Clostridium C1 that exhibits bidirectional enzyme activity and is widely distributed in human and animal gut microbiomes, offering new insights into (S)-equol production and potential applications.

A magnetic field prevents alcoholic liver disease by reducing oxidative stress

This study shows that a specific static magnetic field reduces oxidative stress and liver damage caused by alcohol consumption in mice.

Particle morphology of medusavirus inside and outside the cells reveals a new maturation process of giant viruses

The paper investigates medusavirus morphology and maturation using electron microscopy, revealing a new maturation process with distinct particle types and structural features.

ASF1 activation PI3K/AKT pathway regulates sexual and asexual development in filamentous ascomycete

The paper identifies SeASF1 and SeH4 as regulators of the PI3K/AKT pathway in filamentous ascomycete, influencing sexual and asexual development through interactions with SeDJ-1 and SePI3K.

Proteome-wide screening for mitogen-activated protein kinase docking motifs and interactors

The paper screens for MAPK docking motifs and interactors using a yeast-based genetic pipeline, identifying novel sequences and residues critical for binding to JNK1 and p38.