Enhancing mitochondrial pyruvate metabolism ameliorates myocardial ischemic reperfusion injury.
Joseph R. Visker, Ahmad A. Cluntun, Jesse N. Velasco-Silva, David R. Eberhardt, Thirupura S. Shankar, Rana Hamouche, Jing Ling, Hyoin Kwak, Yanni Hillas, Ian Aist, Eleni Tseliou, Sutip Navankasattusas, Dipayan Chaudhuri, Gregory S. Ducker, Stavros G. Drakos, Jared Rutter
This study shows that inhibiting MCT4 to redirect pyruvate metabolism reduces myocardial ischemia-reperfusion injury by improving mitochondrial function and reducing oxidative stress.
bioRxiv · Feb 1, 2024 · PreprintPhysiology