Jared P. Rutter

Direct mitochondrial import of lactate supports resilient carbohydrate oxidation

This study shows that lactate can be directly imported into mitochondria and oxidized to support cardiac energy production, independent of the pyruvate carrier.

Hyperactivation of β-catenin rewires mitochondrial fuel selection in liver cancer cells

This study shows that β-catenin activation in liver cancer cells reduces mitochondrial pyruvate carrier expression and shifts metabolism from carbohydrate to fatty acid oxidation.

Tirzepatide preserves hematopoietic stem and progenitor cycling while remodeling inflammatory monocytes in obese mice

This study compares the effects of tirzepatide and caloric restriction on hematopoiesis in obese mice, finding tirzepatide preserves HSPC cycling and reduces inflammatory monocytes while CR causes cytopenias.

Identification of genomic features that uniquely impact estrogen receptor alpha binding and its effects on gene expression in endometrial cancer

The paper identifies genomic features affecting ERα binding and gene expression in endometrial cancer, finding cell-type-specific transcription factors and distinct predictive features compared to breast cancer.

Sequence adaptations satisfy the constraints of mitochondrial membrane protein evolution

The paper identifies aliphatic-to-threonine substitutions as a conserved adaptation in mitochondrial membrane proteins that balances hydrophilicity and hydrophobicity requirements.

SLC16A6 is a tyrosine transporter for the melanosome

This study identifies SLC16A6 as the melanosomal tyrosine transporter, showing it is essential for melanosome biogenesis and function.

Lineage specifying transcription factors determine cell function by direct control of metabolism

The paper identifies lineage-specifying transcription factors that directly control metabolism to ensure cell function.

Integrative Clinical-Molecular Modeling Identifies LRRN4CL as a Determinant of Structural and Functional Myocardial Improvement

This paper integrates clinical and transcriptomic data to identify LRRN4CL as a predictor of myocardial recovery in heart failure patients undergoing LVAD therapy, showing its association with cardiomyocyte dysfunction.

Inhibition of FicD-mediated AMPylation and deAMPylation by Isoprenoid Diphosphates

This study identifies geranyl- and farnesyl-pyrophosphate as FicD inhibitors that differentially affect disease-causing variants, providing insights for therapeutic targeting of UPR.

Excessive Ca2+-dependent ER-mitochondrial contact stabilization by EFHD1 drives liver injury

This study identifies EFHD1 as a Ca2+-dependent stabilizer of ER-mitochondrial contacts that drives liver injury in MASH by promoting mitochondrial fragmentation and antiviral stress responses.

The fate of pyruvate dictates cell growth by modulating cellular redox potential

The paper shows that pyruvate metabolism affects cell growth in post-mitotic cells by altering redox balance and metabolic pathways, despite active growth signals.

Peroxisome proliferator-activated receptor gamma (PPARG)-mediated myocardial salvage in acute myocardial infarction managed with left ventricular unloading and coronary reperfusion

This study investigates the mechanisms of myocardial salvage in acute myocardial infarction using left ventricular unloading and reperfusion, identifying PPARG as a key cardioprotective gene and suggesting rosiglitazone as a potential adjuvant therapy.

SLC7A5 is required for citrulline-dependent growth in arginine limited conditions

This study identifies SLC7A5 as essential for citrulline-dependent growth in arginine-limited conditions and shows its role in citrulline uptake and tumor growth.

Enhancing mitochondrial pyruvate metabolism ameliorates myocardial ischemic reperfusion injury.

This study shows that inhibiting MCT4 to redirect pyruvate metabolism reduces myocardial ischemia-reperfusion injury by improving mitochondrial function and reducing oxidative stress.

Recessive pathogenic variants in MCAT cause combined oxidative phosphorylation deficiency

The paper identifies biallelic MCAT variants in a patient with combined oxidative phosphorylation deficiency and shows reduced ETC complex subunits and enzyme activities.

Lactate transport inhibition therapeutically reprograms fibroblast metabolism in experimental pulmonary fibrosis

The paper shows that inhibiting lactate transporters MCT1 and MCT4 reduces myofibroblast differentiation and pulmonary fibrosis in vitro and in vivo.

Paradoxical neuronal hyperexcitability in a mouse model of mitochondrial pyruvate import deficiency

A mouse model with impaired mitochondrial pyruvate import shows neuronal hyperexcitability and seizures despite reduced oxidative phosphorylation.

XPRESSyourself: Enhancing, Standardizing, and Automating Ribosome Profiling Computational Analyses Yields Improved Insight into Data

XPRESSyourself automates and standardizes ribosome profiling analysis, improving reproducibility and enabling new insights into translation regulation.

mTORC1 activates PASK-Wdr5 signaling to epigenetically connect the nutrient status with myogenesis.

The paper shows mTORC1 activates PASK-Wdr5 signaling to epigenetically link nutrient status with myogenesis by promoting Myogenin transcription and differentiation.