Krishnakanth Kondabolu

This study uses AAV2-delivered exon-specific U1 snRNA to correct ELP1 splicing and rescue optic neuropathy in a FD mouse model.

This paper investigates how high frequency electrical stimulation modulates fast spiking interneurons in different brain regions, finding region-specific entrainment and bidirectional effects on temporal processing.

This paper develops a CRISPR base editing strategy to correct the FD-causing mutation in human cells and mice, achieving up to 70% on-target correction and functional restoration.

This paper introduces a microscope combining targeted illumination and confocal gating to improve voltage imaging in dense tissues, enhancing signal-to-noise ratio and reducing crosstalk.

This paper introduces a photothrombotic stroke model in mice that reproduces human epilepsy electrographic biomarkers, showing increased spike ripples and delta power in the stroke hemisphere.

This study identifies a selective subthalamostriatal projection to parvalbumin-expressing interneurons in the striatum, showing higher connectivity and excitatory responses compared to other cell types.

The paper shows that single and complex spikes in hippocampal neurons encode frequency-specific information during spatial navigation, with distinct roles for theta and gamma rhythms.

This study shows that deep brain stimulation (DBS) causes membrane depolarization in hippocampal neurons, impairing their ability to process inputs and creating an information lesion.

The paper identifies an inhibitory pathway from the pedunculopontine nucleus to dopamine neurons that selectively suppresses goal-directed actions.

This study identifies midbrain cholinergic neurons as a major source of acetylcholine in the striatum, showing their role in modulating striatal circuits and action control.

This study shows that activating striatal cholinergic receptors increases beta oscillations in the corticostriatal loop, with directional connectivity and subband-specific effects.