Pre-marked chromatin and transcription factor co-binding shape the pioneering activity of Foxa2.
Filippo M. Cernilogar, Stefan Hasenöder, Zeyang Wang, Katharina Scheibner, Ingo Burtscher, Michael Sterr, Pawel Smialowski, Sophia Groh, Ida M. Evenroed, Gregor D. Gilfillan, Heiko Lickert, Gunnar Schotta
This study shows that Foxa2 binding site selection is influenced by chromatin environment and that chromatin opening requires collaboration with other transcription factors during endoderm differentiation.
Nucleic Acids Research · Jul 15, 2019Peer-reviewedGenomics