Filippo M. Cernilogar

This study uses cerebral organoids to show that EPM1 mutations disrupt neural cell fate specification through intrinsic and extrinsic mechanisms involving EVs and SHH signaling.

The paper investigates how extracellular vesicles (EVs) mediate developmental cues during brain development and disease, finding altered EV composition and function in neurodevelopmental disorders.

The paper identifies BRG1 as a key component of a co-repressor complex that GR uses to repress inflammatory genes in macrophages, revealing a non-classical role for the SWI/SNF complex.

The paper shows that promoter G-quadruplexes and transcription factors like AP-1 and SP1 work together to regulate cell-specific gene expression in liposarcoma and keratinocytes.

This study shows that Foxa2 binding site selection is influenced by chromatin environment and that chromatin opening requires collaboration with other transcription factors during endoderm differentiation.