Gunnar Schotta

The paper develops a chromatin hierarchical lattice framework to predict heterochromatin nanodomains and identifies DNA sequence and protein binding factors that determine their formation and boundaries.

The paper identifies BRG1 as a key component of a co-repressor complex that GR uses to repress inflammatory genes in macrophages, revealing a non-classical role for the SWI/SNF complex.

The paper shows that promoter G-quadruplexes and transcription factors like AP-1 and SP1 work together to regulate cell-specific gene expression in liposarcoma and keratinocytes.

This study identifies Morc3 as a key regulator of ERV silencing by enabling Daxx-mediated H3.3 incorporation, revealing a mechanism for chromatin modification and repression.

This study shows that Foxa2 binding site selection is influenced by chromatin environment and that chromatin opening requires collaboration with other transcription factors during endoderm differentiation.