DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma
Ariunaa Bayanjargal, Cenny Taslim, Iftekhar A Showpnil, Julia Selich-Anderson, Jesse C Crow, Runwei Zhou, Stephen L Lessnick, Emily Rose Theisen
This study investigates the role of the DBD-4 helix in EWSR1::FLI1's binding to GGAA microsatellites, showing its importance in genome regulation and oncogenic transformation in Ewing sarcoma.
bioRxiv · Jan 31, 2024Cancer Biology