Pancreatic Cancer Induces Population-Specific Switching of Myosin Isoforms and Discrete Activation of Cachexia Genes in Skeletal Muscle Myocytes
Brittany R. Counts, Sephora Jean, Omnia U. Gaafer, Sara Ota, Iishaan Inabathini, Tingbo Guo, Denis C. Guttridge D, Michael C. Ostrowski, Leonidas G. Koniaris, Sha Cao, Hyun Cheol Roh, Teresa A. Zimmers
This study identifies population-specific transcriptional changes in skeletal muscle myonuclei during pancreatic cancer cachexia, revealing distinct gene activation patterns rather than uniform upregulation of cachexia mediators.
bioRxiv · Sep 1, 2025 · PreprintCancer Biology