Author

Denis C. Guttridge D

Medical University of South CarolinaORCID 0000-0002-7276-6609Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Abeba ZewduiD· 1 shared Brittany R. CountsiD· 1 shared Danielle BraggioiD· 1 shared David Koller· 1 shared David WangiD· 1 shared Dawn S. ChandleriD· 1 shared Fernanda Costas Casal de FariaiD· 1 shared Gonzalo LopeziD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperMolecular Biology

Abeba ZewduORCID

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2 papers

Recent·Most cited

Molecular BiologyPLoS ONEPeer-reviewedSep 17, 2025

Blockade of Interleukin-6 (IL-6) Signaling in Dedifferentiated Liposarcoma (DDLPS) Decreases Mouse Double Minute 2 (MDM2) Oncogenicity via Alternative Splicing

Abeba Zewdu, Danielle Braggio, Gonzalo Lopez…·Raphael E. Pollock

This study shows that blocking IL-6 signaling in DDLPS reduces MDM2 oncogenicity through alternative splicing, suggesting a potential therapeutic target.

2 citations

mousebulk RNA-seq

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Cancer BiologybioRxivPreprintSep 1, 2025

Pancreatic Cancer Induces Population-Specific Switching of Myosin Isoforms and Discrete Activation of Cachexia Genes in Skeletal Muscle Myocytes

Brittany R. Counts, Sephora Jean, Omnia U. Gaafer…·Teresa A. Zimmers

This study identifies population-specific transcriptional changes in skeletal muscle myonuclei during pancreatic cancer cachexia, revealing distinct gene activation patterns rather than uniform upregulation of cachexia mediators.

DOI 10.1101/2025.09.01.673500

humanscRNA-seq

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