SAICAr-dependent and independent effects of ADSL deficiency on neurodevelopment
Ilaria Dutto, Julian Gerhards, Antonio Herrera, Olga Souckova, Václava Škopová, Jordann A Smak, Alexandra Junza, Óscar Yanes, Cedric A. Boeckx, Martin D. Burkhalter, Marie Zikánová, Sebastián Pons, Melanie Philipp, Jens Lüders, Travis H. Stracker
This study investigates the effects of ADSL deficiency on neurodevelopment, showing both SAICAr-dependent and independent mechanisms contributing to pathologies like microcephaly and autism.
eLife · Feb 8, 2022Peer-reviewedDevelopmental Biology