Cedric A. Boeckx

This study identifies genetic associations between human brain shape (globularity) and brain-related traits, revealing links to cerebellar volume, ventricular size, and metabolic pathways.

The paper maps RNA-chromatin interactions in human prefrontal cortex, revealing co-regulatory changes linked to brain evolution and disease pathways.

The paper longitudinally profiles cerebellar organoids, benchmarks them against fetal data, and models mutations linked to autism and human brain evolution.

The paper uses combinatorial CRISPR-Cas9 perturbations in brain organoids to uncover regulatory hierarchies of human-specific genes involved in cortical evolution.

This study identifies a human-specific CHD2 regulatory variant that influences cortical development tempo via lysosomal homeostasis, showing therapeutic potential through lysosomal restoration.

This study investigates the genetic architecture of cerebellar lobules using UK Biobank data, revealing regional heritability and associations with psychiatric disorders and cognitive traits.

This study investigates the effects of ADSL deficiency on neurodevelopment, showing both SAICAr-dependent and independent mechanisms contributing to pathologies like microcephaly and autism.

The paper uses RNA-seq to analyze gene expression in bovine prefrontal cortex across age stages, identifying age-related gene expression changes linked to aggression and neoteny.

The paper compares oxytocin sequence and expression between domesticated Bengalese finches and wild munias, finding reduced OT mRNA expression in finches.

The paper identifies genetic variations in oxytocin and vasotocin receptors across humans, archaics, and primates, linking them to prosocial traits and evolutionary insights.

The paper identifies modern human alleles that differentially regulate gene expression across brain regions, highlighting positive selection signals and cerebellum specialization.

The paper uses archaic human genome data to argue that SRGAP2 gene duplication contributed to vocal learning in extinct hominins before anatomically modern humans emerged.

This study identifies selective sweep overlaps between Homo sapiens and domesticated species, suggesting self-domestication through altered signaling pathways.