Stéphanie Pons

This paper introduces twin-prime editing to visualize endogenous proteins and track mutant alleles at single-cell resolution in vivo.

This study shows that the interpeduncular nucleus (IPN) regulates nicotine reward by modulating VTA neuron activity through β4-containing nAChRs.

The paper shows nicotine inhibits amygdala-projecting dopamine neurons via a VTA-NAc feedback loop, leading to anxiety.

This study shows that overexpression of CHRFAM7A in human iPSC-derived interneurons reduces surface α7-nAChR and alters ROS response to Aβ1-42.

The paper solves cryo-EM structures of human α7 nicotinic receptor nanobody complexes, revealing E3's mechanism of inducing active or desensitized conformations through a N-linked sugar moiety.

This paper describes the generation of nanobodies that act as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor, with distinct functional properties.

This study investigates the effects of ADSL deficiency on neurodevelopment, showing both SAICAr-dependent and independent mechanisms contributing to pathologies like microcephaly and autism.

This study identifies distinct dopamine circuits in the ventral tegmental area that mediate nicotine's reinforcing and anxiogenic effects through opposing responses in neurons projecting to the nucleus accumbens and amygdala.

The paper identifies a mechanism by which VGLUT1 increases synaptic vesicle clustering, reducing superpool size and spontaneous release frequency through interactions with endophilinA1 and intersectin1.

This study shows that somatic nicotinic acetylcholine receptors in VTA dopamine neurons modulate firing properties and reward-related behaviors through optical manipulation.

The paper shows E proteins differentially cooperate with proneural bHLH transcription factors to sharpen neurogenesis by acting on specific DNA motifs.