Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP
Sindhuja Sridharan, Nils Kurzawa, Thilo Werner, Ina Günthner, Dominic Helm, Wolfgang K. Huber, Marcus Bantscheff, Mikhail M. Savitski
This study quantifies ATP's proteome-wide interactions with protein solubility and thermal stability, revealing concentration-dependent roles in protein structure, complex stability, and phase transitions.
Nature Communications · Mar 11, 2019Peer-reviewedSystems Biology