Dominic Helm

This study shows PAK1 activation leads to different resistance mechanisms against Tamoxifen and aromatase inhibitors in luminal A breast cancer by affecting apoptosis and proliferation through distinct pathways.

This study shows that adenovirus E4orf4 interacts with CDC20 to redirect APC/C-CDC20 towards Aurora B, causing hyperubiquitination and mitotic regression, leading to polyploidy.

This study identifies mRAVE as a mammalian V-ATPase assembly factor that links organelle acidification to function and nutrient signaling.

The paper develops a method to isolate intact engineered extracellular vesicles with high purity using twin-Strep tagging and Strep technology, enabling efficient and selective capture and functional delivery of proteins.

This study uses T-DARPins to inhibit TBXT in chordoma cells, revealing its regulome and identifying therapeutic vulnerabilities, including sensitivity to JAK2 inhibitors.

The paper identifies RNA-dependent proteins in cell division using R-DeeP, revealing new interactions and phosphorylation events involving AURKA, KIFC1, and TPX2.

The paper identifies PROX1 as a safeguard repressor that maintains hepatocyte identity and prevents liver tumourigenesis by repressing alternate fate regulators.

This study investigates how SMARCB1 loss in Epithelioid Sarcoma rewires epigenetic regulation, revealing therapeutic vulnerabilities through functional multi-omics analysis.

This study harmonizes quality controls across proteomics core facilities to improve data comparability and reliability through a 4-year longitudinal dataset and common processing software.

This study compares four lysis buffers for proteomics, finding SDS most reliable and advocating a dual-sample approach to maximize proteome coverage.

The paper identifies 218 C16:0-acylated and 308 C18-lipid-acylated proteins, showing widespread competition for acylation across the proteome.

The paper characterizes aggregation and disaggregation of proteins in human cells after heat shock, identifying factors influencing these processes and their implications for protein quality control.

This study quantifies ATP's proteome-wide interactions with protein solubility and thermal stability, revealing concentration-dependent roles in protein structure, complex stability, and phase transitions.