Author

Thilo Werner

GlaxoSmithKline (Germany)ORCID 0000-0003-0688-5834Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Marcus BantscheffiD· 3 shared Giovanna BergaminiiD· 2 shared Maria Faelth-SavitskiiD· 2 shared Nils KurzawaiD· 2 shared Ania RutkowskaiD· 1 shared Anna Rutkowska· 1 shared Bianca Heller· 1 shared Christina E Rau· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersSystems Biology

Marcus BantscheffORCID

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3 papers

Recent·Most cited

Systems BiologybioRxivPreprintAug 15, 2023

Integration of Thermal Proteome Profiling with phosphoproteomic and transcriptomic data via mechanistic network models decodes the molecular response to PARP inhibition

Mira Lea Burtscher, Stephan Gade, Martín Garrido‐Rodríguez…·Julio Sáez-Rodríguez

The paper integrates Thermal Proteome Profiling with phosphoproteomic and transcriptomic data using network models to uncover molecular responses to PARP inhibition in ovarian cancer.

DOI 10.1101/2023.08.15.553354

humanproteomics

𝕏 PostBluesky

Systems BiologyNature CommunicationsPeer-reviewedMar 11, 2019

Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP

Sindhuja Sridharan, Nils Kurzawa, Thilo Werner…·Mikhail M. Savitski

This study quantifies ATP's proteome-wide interactions with protein solubility and thermal stability, revealing concentration-dependent roles in protein structure, complex stability, and phase transitions.

269 citationstop 1%

humanproteomics

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Cell BiologybioRxivPreprintDec 20, 2018

Proteome thermal stability reflects organ physiology and identifies drug-target engagement in vivo

Jessica Perrin, Thilo Werner, Nils Kurzawa…·Giovanna Bergamini

This study introduces tissue-TPP and blood-CETSA to measure proteome thermal stability, revealing organ physiology and drug-target engagement in vivo.

DOI 10.1101/500306

mouseproteomics

𝕏 PostBluesky