Sindhuja Sridharan

The paper identifies lipoamide as a small molecule that dissolves stress granules and improves outcomes in ALS models by modulating redox-sensitive proteins.

The paper develops a statistical method to analyze thermal proteome profiles and identifies off-target drug interactions in epigenetic drugs.

The paper characterizes aggregation and disaggregation of proteins in human cells after heat shock, identifying factors influencing these processes and their implications for protein quality control.

This study quantifies ATP's proteome-wide interactions with protein solubility and thermal stability, revealing concentration-dependent roles in protein structure, complex stability, and phase transitions.