Nils Kurzawa

The paper introduces iss-nf, a Nextflow-based workflow for analyzing in situ sequencing data, demonstrating its effectiveness on multiple datasets.

The paper introduces a protocol to integrate diverse bioactivity data into the Chemical Checker compound universe, enabling the generation of novel bioactivity signatures for small molecules.

The paper introduces mito-TPP, a thermal proteome profiling workflow for studying mitochondrial protein interactions and proteoforms, detecting over 180 proteins with multiple proteoform groups.

The paper assesses the impact of phosphorylation on protein thermal stability using phospho-TPP in HeLa cells, finding that phosphorylation affects stability less than previously reported.

The paper develops a statistical method to analyze thermal proteome profiles and identifies off-target drug interactions in epigenetic drugs.

The paper characterizes aggregation and disaggregation of proteins in human cells after heat shock, identifying factors influencing these processes and their implications for protein quality control.

This paper introduces NPARC, a non-parametric method for analyzing thermal proteome profiles to identify drug-binding proteins with improved specificity and sensitivity.

This study quantifies ATP's proteome-wide interactions with protein solubility and thermal stability, revealing concentration-dependent roles in protein structure, complex stability, and phase transitions.

This study introduces tissue-TPP and blood-CETSA to measure proteome thermal stability, revealing organ physiology and drug-target engagement in vivo.

The paper introduces a method to disentangle multi-omics data and identifies regulatory mechanisms in human blood cells.