Synthesis of USC-093 and comparison with its promoiety enantiomer USC-093D against adenovirus in vitro and in a Syrian hamster model
Jiayi Yang, Samantha B. Riemann, Jinglei Lyu, Sudi Feng, Yang Bi, Nicholas A. Lentini, Inah Kang, B. A. Kashemirov, Caroll B. Hartline, Scott H. James, Ann E. Tollefson, Anna Cline-Smith, Károly Tóth, Charles E. McKenna
This paper synthesizes USC-093 and its enantiomer USC-093D, comparing their antiviral efficacy against adenovirus in vitro and in a Syrian hamster model, finding no significant improvement in vivo from the D-enantiomer.
bioRxiv · Nov 1, 2024 · PreprintBiochemistry