Author

Károly Tóth

Saint Louis UniversityORCID 0000-0001-6624-9683Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Ann E. TollefsoniD· 2 shared Anna Cline-SmithiD· 2 shared Franck GallardoiD· 2 shared Luigi André AgrofoglioiD· 2 shared Sandrine Kappler‐Gratias· 2 shared Vincent RoyiD· 2 shared Alicia MasiD· 1 shared Alı́ AlejoiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMicrobiology

Ann E. TollefsonORCID

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3 papers

Recent·Most cited

LAVR-289, a New Orally Bioavailable Inhibitor of Adenovirus Replication in vitro and in vivo.

Charlotte Quentin-Froignant, Ann E. Tollefson, Anna Cline-Smith, Sandrine Kappler‐Gratias, Nicolas Landrein, Vincent Roy, Luigi André Agrofoglio, Károly Tóth, Harald Wodrich, Franck Gallardo

This study evaluates LAVR-289, an acyclonucleoside phosphonate, showing potent antiviral activity against adenovirus in vitro and in vivo, with 100% survival in immunocompromised hamsters.

bioRxiv · Feb 20, 2025 · PreprintMicrobiology

In vitro and in vivo Antiviral Activity of the Acyclic Nucleoside Phosphonate Prodrug LAVR-289 against Poxvirus and African Swine Fever Virus Replication

Elie Marcheteau, Estelle Mosca, Gaelle Frénois-Veyrat, Sandrine Kappler‐Gratias, Laetitia Boutin, Sokunthea Top, Thomas Mathieu, Cyril Colas, Patrick Favetta, Tony Garnier, Peggy Barbe, Mathilde Keck, Daniel Gillet, Alicia Mas, Alı́ Alejo, , Franck Gallardo

This study evaluates LAVR-289, a nucleoside analogue, showing antiviral activity against poxviruses and ASFV in vitro and in vivo with no toxicity.

bioRxiv · Feb 20, 2025 · PreprintMicrobiology

Synthesis of USC-093 and comparison with its promoiety enantiomer USC-093D against adenovirus in vitro and in a Syrian hamster model

Jiayi Yang, Samantha B. Riemann, Jinglei Lyu, Sudi Feng, Yang Bi, Nicholas A. Lentini, Inah Kang, B. A. Kashemirov, Caroll B. Hartline, Scott H. James, Ann E. Tollefson, Anna Cline-Smith, Károly Tóth, Charles E. McKenna

This paper synthesizes USC-093 and its enantiomer USC-093D, comparing their antiviral efficacy against adenovirus in vitro and in a Syrian hamster model, finding no significant improvement in vivo from the D-enantiomer.

bioRxiv · Nov 1, 2024 · PreprintBiochemistry