Tumour-derived extracellular vesicles within the therapy-induced senescent secretome distinctly suppress breast cancer via DKK1-mediated inflammatory response.
Matius Robert, Rekha Jakhar, Bijin Veonice Au, Gracie Wee Ling Eng, Meng Wei, Alvin Kunyao Gao, You Heng Chuah, Karishma Sachaphibulkij, Isabelle Bonne, Kah Jing Lim, Indrajit Sinha, Daniel Boon Loong Teh, Lina H. K. Lim, Prashant Kumar, Navin Kumar Verma, , Karen Crasta
This study identifies that TIS-derived extracellular vesicles suppress breast cancer through DKK1-mediated inflammation, contrasting with the pro-tumorigenic effects of the senescence-associated secretome.
bioRxiv · Mar 29, 2024 · PreprintCancer Biology