Lina H. K. Lim

TRPM7 Annexin A1 Mechanosensitive Pathway Drives Capillary Infiltration by Circulating Tumor Cells

The paper identifies a TRPM7-Annexin A1 pathway that enables circulating tumor cells to adapt to fluid shear stress in capillaries, facilitating metastasis.

Tumour-derived extracellular vesicles within the therapy-induced senescent secretome distinctly suppress breast cancer via DKK1-mediated inflammatory response.

This study identifies that TIS-derived extracellular vesicles suppress breast cancer through DKK1-mediated inflammation, contrasting with the pro-tumorigenic effects of the senescence-associated secretome.

Spatially informed clustering, integration, and deconvolution of spatial transcriptomics with GraphST

GraphST improves spatial transcriptomics analysis by integrating clustering, integration, and deconvolution through graph self-supervised contrastive learning, achieving higher accuracy than existing methods.

AIM2 Inflammasome Mediates Hallmark Neuropathological Alterations and Cognitive Impairment in a Mouse Model of Vascular Dementia

This study shows that AIM2 inflammasome activation contributes to brain injury and cognitive impairment in a mouse model of vascular dementia.