Metabolic profiling of cultured erythroblast for the production of transfusion-ready cultured red blood cells
Joan Sebastián Gallego‐Murillo, Ingeborg van Lakwijk, Nurcan Yağcı, Julie A. Reisz, Victoria Pozo Garcia, Angelo D'Alessandro, Luuk A. M. van der Wielen, Marieke v. Lindern, A. Wahl, Emile van den Akker
This study identifies metabolic stress in high-density erythroblast cultures, showing that small molecular weight metabolites limit proliferation and suggesting strategies to improve cell productivity.
bioRxiv · Jun 2, 2026 · PreprintCell Biology