Julie A. Reisz

Metabolic vulnerabilities in Down syndrome B-cell acute lymphoblastic leukemia can be targeted using Venetoclax

This study identifies metabolic vulnerabilities in Down syndrome B-cell acute lymphoblastic leukemia and shows that Venetoclax effectively targets these vulnerabilities.

Nuclear acetyl-CoA accumulation drives reversible RBP hyperacetylation and transcriptome-wide splicing shifts in age-equivalent Alzheimer's disease neurons

This study shows that nuclear acetyl-CoA accumulation in Alzheimer's disease neurons causes RBP hyperacetylation and splicing shifts, which can be reversed by inhibiting ACLY.

The Nicotinamide Salvage Pathway is a Metabolic Vulnerability of High-Risk MDS Stem Cells

This study identifies NAMPT as a metabolic vulnerability in HR-MDS HSPCs, showing its inhibition reduces their survival and disease burden.

Metabolic profiling of cultured erythroblast for the production of transfusion-ready cultured red blood cells

This study identifies metabolic stress in high-density erythroblast cultures, showing that small molecular weight metabolites limit proliferation and suggesting strategies to improve cell productivity.

Magnetic Levitation Derived Metabolomic Fingerprinting Enables Exploratory Discrimination of Breast Cancer Subtypes

This study uses magnetic levitation and metabolomics to distinguish breast cancer subtypes by their unique metabolic fingerprints.

A population-scale red blood cell proteome reveals genetically encoded aging clocks predictive of hemolysis and blood donor activity

This paper characterizes the RBC proteome across 13,091 donors, identifies genetic regulators of molecular aging, and shows that aging clocks predict hemolysis, transfusion outcomes, and donor activity.

Aberrant oxidative metabolism selects for TET2-deficient hematopoietic stem and progenitor cells

This study shows that aberrant oxidative metabolism drives the selection of TET2-deficient hematopoietic stem and progenitor cells in clonal hematopoiesis, with the pentose phosphate pathway playing a compensatory role.

Incorporation of microbially salvaged urea-nitrogen into anabolic amino acids during hibernation in arctic ground squirrels

The paper investigates urea-nitrogen salvage in hibernating arctic ground squirrels, finding higher incorporation of microbial urea into amino acids during hibernation compared to summer activity.

Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric Leukemia

This study shows that the developmental stage of hematopoietic stem cells influences leukemic transformation, lineage hierarchy, and therapy response in pediatric leukemia.

Deep Red Blood Cell Proteome Defines the Band 3 N-Terminus Interactome as a Regulator of Hypoxic Adaptation via BLVRB-Dependent S-Nitroso Transfer

The paper defines the Band 3 N-terminus interactome in red blood cells, revealing its role in hypoxic adaptation through BLVRB-dependent S-nitroso transfer and metabolic remodeling.

Structural divergence of G6PD variants shapes red blood cell storage and transfusion performance

The paper investigates how G6PD variants affect red blood cell storage, transfusion performance, and recipient physiology using multiple datasets and experimental models.

Caffeine Impairs Red Blood Cell Storage Quality by Dual Inhibition of ADORA2b Signaling and G6PD Activity

Caffeine consumption and ADORA2b genetic variants impair RBC metabolism and transfusion outcomes through dual mechanisms, highlighting a modifiable interaction for precision transfusion strategies.

Early adipose tissue wasting in a novel preclinical model of human lung cancer cachexia

This study develops a novel mouse model of human lung cancer cachexia that exhibits early adipose tissue wasting and metabolic reprogramming, mirroring human disease features.

Chemoresistance of TP53 mutant AML requires the mevalonate byproduct, GGPP, for regulation of ROS and induction of a mitochondria stress response

This study identifies GGPP, a mevalonate pathway byproduct, as critical for chemoresistance in TP53mut AML through ROS regulation and mitochondria stress response, suggesting statin-based therapies could be effective.

Integrative Multi-Omics Analysis Identifies Nuclear Factor I as a Key Driver of Dysregulated Purine Metabolism in DIPG

This study identifies nuclear factor I (NFI) as a driver of dysregulated purine metabolism in DIPG, showing that targeting ATIC reduces tumor progression in mice.

Genetic architecture of the red blood cell proteome in genetically diverse mice reveals central role of hemoglobin beta cysteine redox status in maintaining circulating glutathione pools

The paper identifies genetic factors influencing red blood cell proteome and oxidative stress in mice, highlighting hemoglobin cysteine redox status as critical for glutathione regulation.

Increased Cholesterol Synthesis Drives Neurotoxicity in Patient Stem Cell-Derived Model of Multiple Sclerosis

This study identifies increased cholesterol synthesis in PMS patient-derived neural progenitor cells as a driver of neurotoxicity, which can be mitigated by simvastatin.

Activated Interferon Signaling Suppresses Age-Dependent Liver Cancer

This study shows that aged livers have heightened interferon signaling that suppresses cancer but also has harmful effects, leading to a 'precarious balance' in tumor development.

Mitochondrial reverse electron transport in myeloid cells perpetuates neuroinflammation

The paper identifies mitochondrial reverse electron transport in myeloid cells as a driver of neuroinflammation and shows that blocking it protects the CNS in disease models.

Metabolomic analysis of Drosophila melanogaster larvae lacking Pyruvate kinase

This study investigates the metabolic effects of Pyruvate kinase (Pyk) loss in Drosophila larvae, revealing disrupted glycolysis and compensatory metabolic changes.

Multi-Omic Analysis Reveals Cannabidiol Disruption of Cholesterol Homeostasis in Human Cell Lines

This study shows CBD disrupts cholesterol homeostasis in human cell lines, altering metabolites, transcripts, and proteins related to cholesterol biosynthesis, transport, and storage.