Emile van den Akker

This study identifies metabolic stress in high-density erythroblast cultures, showing that small molecular weight metabolites limit proliferation and suggesting strategies to improve cell productivity.

The paper shows that deleting intervening DNA can bring enhancers closer to silenced genes, reactivating their expression in adult cells.

The paper analyzes circRNA expression during hematopoietic differentiation and finds limited evidence for their translation or regulatory role in erythroid and megakaryoid cells.

The paper evaluates sgRNA design for spCas9-RNP gene editing in HSPCs, showing in vitro screening outperforms in silico models and no adverse effects on cell function.

This paper introduces a standardized, feeder-free protocol to efficiently produce erythroid, megakaryoid, and myeloid cells from single-cell-derived iPSC colonies without pre-purification or transcription factor overexpression.

This study identifies Csde1-bound transcripts in erythropoiesis and shows that Csde1 regulates their expression through effects on mRNA stability and translation.