Marieke v. Lindern

This study identifies metabolic stress in high-density erythroblast cultures, showing that small molecular weight metabolites limit proliferation and suggesting strategies to improve cell productivity.

This study shows that erythroblasts adapt to shear stress by accelerating maturation and upregulating cholesterol biosynthesis, enhancing osmotic resistance and enucleation.

The paper analyzes circRNA expression during hematopoietic differentiation and finds limited evidence for their translation or regulatory role in erythroid and megakaryoid cells.

The paper investigates the effects of the Klf1 Nan variant on erythroid maturation, finding that it causes nuclear condensation defects and deregulates Xpo7 expression.

This paper introduces a standardized, feeder-free protocol to efficiently produce erythroid, megakaryoid, and myeloid cells from single-cell-derived iPSC colonies without pre-purification or transcription factor overexpression.

This study identifies Csde1-bound transcripts in erythropoiesis and shows that Csde1 regulates their expression through effects on mRNA stability and translation.

This study identifies Strap as a key partner of Csde1 in erythroblasts, showing that their complex regulates the translation of transcripts critical for erythropoiesis and hypoxia response.