Angelo D’Alessandro

This study identifies age-associated repression of HNF4α as a driver of liver metabolic dysfunction and shows that restoring HNF4α can reverse some age-related liver defects.

This study identifies CHKA's role in alkylating agent resistance through lipid droplet-mediated regulation of RAD51 transcription in T-ALL.

This study shows maternal folate levels influence adult hematopoietic stem cell function through mitochondrial and chromatin changes in offspring.

This study identifies metabolic vulnerabilities in Down syndrome B-cell acute lymphoblastic leukemia and shows that Venetoclax effectively targets these vulnerabilities.

The paper identifies a female-specific microglial redox program that influences susceptibility to obesity by modulating metabolic resilience and mTORC1 signaling.

This study investigates the effect of low-dose ethanol on supercooled red blood cell storage, finding it reduces hemolysis and lysophospholipid depletion while preserving energy homeostasis.

This study identifies NAMPT as a metabolic vulnerability in HR-MDS HSPCs, showing its inhibition reduces their survival and disease burden.

This study shows that loss of lactate dehydrogenase in Drosophila causes exercise intolerance and diet-dependent lethality, mirroring human LDH-A deficiency symptoms.

The paper identifies genetic regulators of the murine serum metabolome, highlighting carboxyl esterases as key controllers of fatty acid metabolism.

This study identifies shared age-associated pathway remodeling across species using comparative metabolomics, highlighting lipid and nucleotide pathways as core features of aging.

This study identifies a distinct mitochondrial metabolic phenotype in sedentary individuals using non-invasive CPET and finds reduced mitochondrial function and bioenergetics compared to active individuals.

This study shows PFOA exposure accelerates Drosophila melanogaster juvenile development and disrupts mitochondrial metabolism, leading to increased sensitivity to environmental stress.

The paper investigates the interaction between U1 snRNP and RNA polymerase II in yeast, finding that Prp40, not U1-70K, mediates this interaction, contrasting with the human system.

This study identifies metabolic stress in high-density erythroblast cultures, showing that small molecular weight metabolites limit proliferation and suggesting strategies to improve cell productivity.

This study links metabolic and inflammatory changes to arterial stiffness in ultra-endurance runners using multi-omics analysis of plasma samples.

This paper characterizes the RBC proteome across 13,091 donors, identifies genetic regulators of molecular aging, and shows that aging clocks predict hemolysis, transfusion outcomes, and donor activity.

This study shows that aberrant oxidative metabolism drives the selection of TET2-deficient hematopoietic stem and progenitor cells in clonal hematopoiesis, with the pentose phosphate pathway playing a compensatory role.

This study shows that red blood cells act as a primary glucose sink under hypoxia, improving glucose tolerance and offering therapeutic potential for diabetes.

This study shows that long-distance trail running causes inflammation, lipid, and purine oxidation in red blood cells, indicating systemic inflammation and metabolic changes as key factors in RBC damage.

This study identifies conserved molecular responses to arsenite exposure in Drosophila, revealing shared pathways with human arsenic-related diseases.

This study shows that the developmental stage of hematopoietic stem cells influences leukemic transformation, lineage hierarchy, and therapy response in pediatric leukemia.

The paper defines the Band 3 N-terminus interactome in red blood cells, revealing its role in hypoxic adaptation through BLVRB-dependent S-nitroso transfer and metabolic remodeling.

The paper investigates how G6PD variants affect red blood cell storage, transfusion performance, and recipient physiology using multiple datasets and experimental models.

This study identifies a proliferative-to-quiescent switch in microglial development and links it to epigenetic regulation and phagocytic function.

This study shows Wolbachia supports Drosophila development and buffers against nutritional stress by altering metabolism and gene expression.

Caffeine consumption and ADORA2b genetic variants impair RBC metabolism and transfusion outcomes through dual mechanisms, highlighting a modifiable interaction for precision transfusion strategies.

This study develops a novel mouse model of human lung cancer cachexia that exhibits early adipose tissue wasting and metabolic reprogramming, mirroring human disease features.

This study identifies BM adipocyte-derived Resistin, regulated by RXR signaling, as critical for HSC self-renewal and hematopoietic regeneration after myeloablation.

This study identifies GGPP, a mevalonate pathway byproduct, as critical for chemoresistance in TP53mut AML through ROS regulation and mitochondria stress response, suggesting statin-based therapies could be effective.