SATB1 maintains naive-like identity in antiviral CD8⁺ T cells by limiting chromatin remodelling at effector gene loci.
Jason K.C. Lee, Adele A. Barugahare, Ioanna Gemund, Jasmine Li, Jessie O’Hara, Michaël Chopin, Daniel Thiele, Maryam Azme, Thomas Bruer, Nicole L. La Gruta, Marc Beyer, Joachim Ludwig Schultze, Brendan E. Russ, Stephen T. Turner
This study identifies SATB1 as a regulator that maintains naive CD8+ T cell identity by restricting chromatin remodelling at effector gene loci, preventing premature differentiation during viral infection.
bioRxiv · Jul 27, 2025 · PreprintImmunology