Marc Beyer

ConvexGating automatically learns unbiased, interpretable gating strategies for flow cytometry data, improving consistency and reducing contamination in cell population identification.

This study compares T cell development in humanized mice with and without murine MHC, finding that busulfan conditioning in MHC-deficient mice promotes activated T cells while irradiation favors naive T cells.

The paper investigates how ischemic injury affects microglial response to Aβ pathology, finding a protective microglial phenotype that promotes benign Aβ plaque formation.

This study shows that IgLON5 autoantibodies cause neuronal hyperactivity and Tau pathology by clustering cell surface proteins, linking them to neurodegeneration.

The paper develops an in vitro platform to screen immune senomodulators using human-derived immune cells, enabling personalized anti-aging treatments through multi-scale molecular analysis.

This study shows that increased somatodendritic Tau interacts with nuclear envelope proteins, causing nuclear damage and altering gene expression related to AD and tauopathies.

This study shows that Satb1 downregulation prevents autoimmunity by maintaining Tfh cell homeostasis and preventing excessive GC formation and auto-antibody secretion.

The paper identifies OSMR and SST as molecular markers for human dermal sleeping nociceptors, providing new therapeutic targets for neuropathic pain.

This paper develops a 3D cortical brain tissue model with mature microglia that recapitulates Alzheimer's disease hallmarks and enables study of microglia phenotypes.

This study shows that yolk sac-derived Kupffer cells regulate neonatal hepatocyte metabolism via Igf1 signaling, essential for glycogen storage and TCA cycle function.

The paper introduces searchSTR, a tool for genome-wide STR somatic instability analysis, and finds associations between STR instability and age, sex, brain morphology, and neurodegeneration markers.

This study identifies molecular factors shaping brain-resident CD8+ T cell formation and function in health and disease.

This study shows that primary cilia dysfunction in Bbs8-/- mice reduces adipose stem cells and promotes fibrogenic progenitors via disrupted Hedgehog signaling, affecting adipogenesis and lipid uptake.

This study identifies SATB1 as a regulator that maintains naive CD8+ T cell identity by restricting chromatin remodelling at effector gene loci, preventing premature differentiation during viral infection.

The paper introduces cyCONDOR, a computational framework for high-dimensional cytometry data analysis, offering scalable and user-friendly tools for preprocessing, clustering, and downstream biological interpretation.

The paper characterizes human CMV-specific CD8+ T cells using a five-layer multi-omics approach and identifies novel T cell receptor sequences for CMV epitopes.

This study shows that Trim71 deficiency during gastrulation disrupts gene expression, leading to defects in erythropoiesis and vascular development, causing embryonic lethality.

This study investigates the cell type-specific roles of AhR and AhRR in diet-induced obesity and fibrosis, finding that AhRR deficiency protects from metabolic dysfunction and liver damage, while AhR deficiency worsens outcomes.

The paper identifies fetal liver macrophage subpopulations and shows their role in regulating granulopoiesis and the HSC niche during embryogenesis.

This paper introduces Metadatasheet, a metadata standard designed to improve data management by aligning with the data-lifecycle and enabling structured metadata recording in Microsoft Excel.

This study identifies two independent mechanisms by which TRIM71 inhibits let-7 miRNA maturation and activity, impacting developmental and oncogenic processes.

This study uses single-cell RNA-seq and computational methods to analyze macrophage states in COPD patients, revealing transcriptional changes and metabolic shifts associated with the disease.

This study investigates how IL4 signalling and NCOR2 regulate the reprogramming of human monocytes into dendritic cells and macrophages, revealing distinct transcriptional and functional profiles based on cytokine exposure timing.