Author

Jacob Neeves

The Francis Crick InstituteORCID 0000-0001-7051-4961Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Giulia E. TyzackiD· 3 shared Raphaëlle LuisieriD· 3 shared Rickie PataniiD· 3 shared Doaa M. TahaiD· 2 shared Hamish CrerariD· 2 shared Nicholas M. LuscombeiD· 2 shared Ione Meyer· 1 shared Jamie S. MitchelliD· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersNeuroscience

Giulia E. TyzackORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintJan 27, 2021

Diminished miRNA activity is associated with aberrant cytoplasmic intron retention in ALS pathogenesis

Marija Petrić, Hamish Crerar, Jacob Neeves…·Raphaëlle Luisier

The paper identifies cytoplasmic intron-retaining transcripts (IRTs) associated with miRNA activity changes in ALS, showing VCP mutations increase IR and target gene expression.

DOI 10.1101/2021.01.27.428555

humanbulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintJul 20, 2020

An aberrant cytoplasmic intron retention programme is a blueprint for ALS-related RBP mislocalization

Giulia E. Tyzack, Jacob Neeves, Pierre Klein…·Rickie Patani

The paper identifies aberrant cytoplasmic intron-retaining transcripts (IRTs) in ALS and shows their association with RBP mislocalization.

2 citations

humanbulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintApr 9, 2019

Widespread FUS mislocalization is a molecular hallmark of ALS

Giulia E. Tyzack, Raphaëlle Luisier, Doaa M. Taha…·Rickie Patani

The paper investigates FUS mislocalization in ALS, finding it occurs in both VCP-mutation related and sporadic ALS, and links it to aberrant intron retention in SFPQ transcripts.

2 citations

humanmouse

𝕏 PostBluesky