Unveiling the Molecular Mechanisms of the Type-IX Secretion System's Response Regulator: Structural and Functional Insights
Anshu Saran, Hey‐Min Kim, Ireland Manning, Mark A. Hancock, Claus Schmitz, Mariusz Madej, Jan Potempa, Marı́a Solà, Jean‐François Trempe, Yongtao Zhu, Mary Ellen Davey, Natalie Zeytuni
This study characterizes PorX, a response regulator in the Type-IX secretion system, revealing its unique enzymatic activity and zinc-dependent dimerization, with implications for virulence factor secretion in bacterial pathogens.
PNAS Nexus · Jul 31, 2024Peer-reviewedBiochemistry