Anshu Saran

This study determines the structure and mechanism of UbK1, a bacterial kinase in P. gingivalis, identifies PorX as a noncanonical substrate, and shows UbK1's role extends beyond canonical secretion pathways.

The paper investigates two pathogenic parkin mutations in the RING2 domain, showing impaired ubiquitin binding and activity through biochemical assays and AlphaFold modeling.

This study characterizes PorX, a response regulator in the Type-IX secretion system, revealing its unique enzymatic activity and zinc-dependent dimerization, with implications for virulence factor secretion in bacterial pathogens.