This study identifies miropin, a prokaryotic serpin from Tannerella forsythia, which suppresses neutrophil antimicrobial activity by inhibiting serine proteases and myeloperoxidase, promoting bacterial survival in vivo.

bioRxiv · Oct 9, 2026 · PreprintImmunology

Discovery of a distinct BAM complex in the Bacteroidetes

Augustinas Silale, Mariusz Madej, Katarzyna Mikruta, Andrew Michael Frey, Adam J. Hart, Arnaud Baslé, Carsten Scavenius, Jan J. Enghild, Matthias Trost, Robert P. Hirt, Bert van den Berg

The paper identifies a distinct BAM complex in Bacteroidetes using structural biology and proteomics, revealing an expanded role compared to Proteobacteria.

Nature Microbiology · Oct 1, 2025Peer-reviewedMicrobiology

Unveiling the Molecular Mechanisms of the Type-IX Secretion System's Response Regulator: Structural and Functional Insights

Anshu Saran, Hey‐Min Kim, Ireland Manning, Mark A. Hancock, Claus Schmitz, Mariusz Madej, Jan Potempa, Marı́a Solà, Jean‐François Trempe, Yongtao Zhu, Mary Ellen Davey, Natalie Zeytuni

This study characterizes PorX, a response regulator in the Type-IX secretion system, revealing its unique enzymatic activity and zinc-dependent dimerization, with implications for virulence factor secretion in bacterial pathogens.

PNAS Nexus · Jul 31, 2024Peer-reviewedBiochemistry