Author

Irene Lam

Calico Life Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Ecology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Assay:whole-genome sequencing· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Nicole L. Fong· 3 shared David G. HendricksoniD· 2 shared Margaret A. RoyiD· 2 shared Andrea T. Ireland· 1 shared Anil RajiD· 1 shared Calvin H. JaniD· 1 shared Danila S. KostiniD· 1 shared Daphna RothschildiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Nicole L. Fong

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Ribosomal DNA copy number variation shapes human physiology and disease risk

Anil Raj, Jordan Brown, Nathaniel H. Thayer, Manuel Hotz, Irene Lam, Nicole L. Fong, Elena P. Sorokin, Marjola Thanaj, Daphna Rothschild, Jonathan K. Pritchard, Maria Barna, David G. Hendrickson

The paper analyzes rDNA copy number variation in humans, finding distinct associations with metabolic diseases and growth traits.

medRxiv · Jan 13, 2026 · PreprintGenetic & Genomic Medicine

Geographic distribution of genetic diversity of Heterocephalus glaber analyzed using whole genome sequencing and a chromosome-scale genome assembly

Kevin M. Wright, Pranidhi Sood, Elena D. Zemlemerova, Danila S. Kostin, Nicole L. Fong, Nelda Yi, Andrea T. Ireland, Irene Lam, Kaitlyn N. Lewis Hardell, Megan Smith, Jackie Villalta, Calvin H. Jan, Margaret A. Roy, David Botstein, Leonid A. Lavrenchenko, , Rochelle Buffenstein

The paper analyzes genetic diversity in naked mole-rats from Kenya and Ethiopia using whole-genome sequencing and a chromosome-scale genome assembly, revealing unexpected genetic divergence patterns.

Frontiers in Ecology and Evolution · Nov 24, 2025Peer-reviewedEcology

Solo: doublet identification via semi-supervised deep learning

Nicholas Bernstein, Nicole L. Fong, Irene Lam, Margaret A. Roy, David G. Hendrickson, David R. Kelley

Solo identifies doublets in scRNA-seq data using semi-supervised deep learning, improving accuracy over existing methods.

bioRxiv · Nov 14, 2019 · PreprintBioinformatics