Daphna Rothschild

Ribosomal DNA copy number variation shapes human physiology and disease risk

The paper analyzes rDNA copy number variation in humans, finding distinct associations with metabolic diseases and growth traits.

Ribosome heterogeneity arising from common and rare rRNA sequence variants affects diverse human phenotypes

The paper identifies rRNA sequence variants affecting human traits and diseases by analyzing UK Biobank data and developing the RiboVAn method.

Diversity of ribosomes at the level of rRNA variation associated with human health and disease

This study identifies and characterizes rRNA variants in human tissues and cancer, revealing tissue-specific ribosome subtypes and cancer-specific ribosome variations.

Deep sequencing of a large family of isogenic mice enables complex variants discovery and accurate phenotype mapping

The paper uses linked-read whole-genome sequencing to identify DNA variants in BXD mice and maps them to phenotypes, enabling systems genetics and precision medicine.

An atlas of robust microbiome associations with phenotypic traits based on large-scale cohorts from two continents

The paper constructs a microbiome-phenotype atlas using large cohorts from Israel and the U.S., showing robust associations and high prediction accuracy across continents.

Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics

This study develops PERSIST-seq and In-line-seq to optimize mRNA stability and translation, finding that in-cell stability is more critical than ribosome load for protein output.

Non-Coding Genetic Analysis Implicates Interleukin 18 Receptor Accessory Protein 3'UTR in Amyotrophic Lateral Sclerosis

The paper identifies non-coding variants in the IL18RAP 3'UTR that reduce ALS risk by modulating neuro-inflammation through NF-κB signaling in microglia.

Large-scale association analyses identify host factors influencing human gut microbiome composition

The paper identifies 31 host genetic loci influencing gut microbiome composition through GWAS and suggests causal effects in inflammatory diseases.

Environmental factors dominate over host genetics in shaping human gut microbiota composition

This study shows environmental factors have a greater impact on human gut microbiota than host genetics, with microbiome data adding significant predictive value to phenotypes.