nSMase2-mediated exosome secretion shapes the tumor microenvironment to immunologically support pancreatic cancer
Audrey M. Hendley, Sudipta Ashe, Atsushi Urano, Martin Ng, Tuan Anh Phu, Xianlu L. Peng, Changfei Luan, Anna‐Marie Finger, Gun Ho Jang, Natanya R. Kerper, David I. Berrios, David S. Jin, Jonghyun Lee, Irene Riahi, Oghenekevwe M. Gbenedio, , Matthias Hebrok
This study shows that eliminating nSMase2 in pancreatic cancer reduces tumor growth, promotes a less aggressive tumor subtype, and enhances immune responses by altering exosome production and macrophage polarization.
bioRxiv · Sep 23, 2024 · PreprintCancer Biology