A FZD4/LRP5 agonist restores pericyte coverage and vascular integrity by increasing PDGFB signaling
Jacklyn Levey, Miranda Howe, Kaia Douglas, Emmanuel Odame, Neal Rajvansh, Ha‐Neul Jo, Lingling Zhang, Christina Chung, Heidi Roehrich, Somasekar Seshagiri, Stéphane Angers, Zhe Chen, Harald J. Junge
This study shows that an FZD4/LRP5 agonist improves pericyte coverage and vascular integrity by enhancing PDGFB signaling in a mouse model of pericyte deficiency.
bioRxiv · Mar 17, 2026 · PreprintDevelopmental Biology