Xianlu L. Peng

This study shows that eliminating nSMase2 in pancreatic cancer reduces tumor growth, promotes a less aggressive tumor subtype, and enhances immune responses by altering exosome production and macrophage polarization.

SCISSORS identifies rare cell types in scRNA-seq data through semi-supervised reclustering and marker gene detection.

The paper uses single-cell RNA sequencing to analyze murine pancreatic duct cells, identifying heterogeneity and functional roles in disease progression.

This study develops a CRISPR/Cas9/AAV9-sgRNA system for in vivo genome editing in muscle satellite cells to investigate key transcription factors during activation and regeneration.

DECODER deconvolves tumor samples to estimate compartment weights, showing clinical relevance in pancreatic cancer and applicability to other data types.