Author

Changfei Luan

University of North Carolina at Chapel Hill

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Jen Jen YehiD· 5 shared David W. DawsoniD· 2 shared Grace E. Kim· 2 shared Ian C. McCabeiD· 2 shared Alan G. Zhang· 1 shared Alexander Lee· 1 shared Alexander LiiD· 1 shared Alina Cornelia IugaiD· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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5 shared papersCancer Biology

Jen Jen YehORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

NEIL2 regulates RNA polymerase II dynamics to suppress transcription replication conflicts in pancreatic cancer

Fan Meng, Anthony Fernandez, Changfei Luan, Marc A. Attiyeh, Qianhua Feng, Alexander Lee, Haihua Feng, Tiane Li, Tingting Zhou, Yun Li, Russell C. Rockne, Terence Williams, David W. Dawson, 沈丙辉, Jen Jen Yeh, , Mustafa Raoof

This study identifies NEIL2 as a regulator of RNA polymerase II dynamics that suppresses transcription replication conflicts in pancreatic cancer cells.

bioRxiv · Oct 20, 2026 · PreprintMolecular Biology

Context-specific genetic interaction mapping reveals combinatorial KRAS/FGFR dependence in pancreatic cancer

Richard Y. Ebright, Yao He, Alan G. Zhang, Ian C. McCabe, Chinmaya U. Joisa, Tanay Thakar, Jayu Jen, Dennie Tompers Frederick, Arianny Acosta, Guangyan Li, Elena Kuehner, Vivian Yang, Katherine E Doherty, Natnael Yaregal, Ngan N. K. Van, , William R. Sellers

The paper identifies combinatorial KRAS/FGFR dependence in pancreatic cancer through genetic interaction mapping and shows that combined inhibition overcomes resistance.

bioRxiv · Sep 25, 2026 · PreprintCancer Biology

Determination of permissive and restraining cancer-associated fibroblast (DeCAF) subtypes

Xianlu Laura Peng, Ian C. McCabe, Elena V. Kharitonova, Yi Xu, Ryan T. Zhao, Changfei Luan, Joseph F. Kearney, Nancy Porterfield Kren, Arthi Hariharan, Jaewon James Lee, Justin Su, P. Chan, Ashley B. Morrison, Michelle E. LaBella, Silvia G. Hererra, , Jen Jen Yeh

The paper develops a classifier, DeCAF, to identify permissive and restraining cancer-associated fibroblast subtypes from bulk RNAseq data and validates its clinical relevance across multiple cancer types.

Cell Reports Medicine · Feb 1, 2026Peer-reviewedGenomics

PCSK9 dependent cholesterol acquisition and utilization underlies metastatic organ preference in pancreatic cancer.

Gilles Rademaker, Grace A. Hernandez, Sumena Dahal, Lisa Miller‐Phillips, Alexander Li, Changfei Luan, Longhui Qui, Maude A. Liegeois, Bruce Wang, Kwun Wah Wen, Grace E. Kim, Eric Andrew Collisson, Stephan Krüger, Stefan Hubert Boeck, Steffen Ormanns, , Rushika M. Perera

This study identifies PCSK9 as a key determinant of metastatic organ preference in pancreatic cancer by regulating cholesterol acquisition and utilization in liver versus lung environments.

bioRxiv · Apr 22, 2025 · PreprintCancer Biology

nSMase2-mediated exosome secretion shapes the tumor microenvironment to immunologically support pancreatic cancer

Audrey M. Hendley, Sudipta Ashe, Atsushi Urano, Martin Ng, Tuan Anh Phu, Xianlu L. Peng, Changfei Luan, Anna‐Marie Finger, Gun Ho Jang, Natanya R. Kerper, David I. Berrios, David S. Jin, Jonghyun Lee, Irene Riahi, Oghenekevwe M. Gbenedio, , Matthias Hebrok

This study shows that eliminating nSMase2 in pancreatic cancer reduces tumor growth, promotes a less aggressive tumor subtype, and enhances immune responses by altering exosome production and macrophage polarization.

bioRxiv · Sep 23, 2024 · PreprintCancer Biology