Multicellular signaling and partial recovery define reverse cardiac remodeling
Marco Steier, Inés Rivero-García, Ricardo O. Ramirez Flores, Anushka Deshpande, Julian Poetzsch, Sumra Nazir, Irsiya Aijaz, Marina Talamini, Volker Ast, Katharina Mößinger, Matthias Dewenter, Benjamin Meder, Manju Kumari, Johannes Backs, Ashraf Yusuf Rangrez, , Norbert Frey
This study shows that reverse cardiac remodeling is a constrained multicellular state with partial recovery of metabolic programs but persistent inflammatory-mitochondrial dysfunction, mediated by lymphatic-derived Reelin.
bioRxiv · Jan 12, 2026 · PreprintMolecular Biology