Author

Sumra Nazir

Heidelberg University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Physiology· 1

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Johannes BacksiD· 2 shared Matthias DewenteriD· 2 shared Ahmed ElwakieliD· 1 shared Alba SulajiD· 1 shared Alireza SaadatmandiD· 1 shared Almut SchulzeiD· 1 shared Anushka DeshpandeiD· 1 shared Ashraf Yusuf RangreziD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersMolecular Biology

Johannes BacksORCID

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3 papers

Recent·Most cited

Multicellular signaling and partial recovery define reverse cardiac remodeling

Marco Steier, Inés Rivero-García, Ricardo O. Ramirez Flores, Anushka Deshpande, Julian Poetzsch, Sumra Nazir, Irsiya Aijaz, Marina Talamini, Volker Ast, Katharina Mößinger, Matthias Dewenter, Benjamin Meder, Manju Kumari, Johannes Backs, Ashraf Yusuf Rangrez, , Norbert Frey

This study shows that reverse cardiac remodeling is a constrained multicellular state with partial recovery of metabolic programs but persistent inflammatory-mitochondrial dysfunction, mediated by lymphatic-derived Reelin.

bioRxiv · Jan 12, 2026 · PreprintMolecular Biology

CAMK2-NR4A1 signaling initiates metabolic substrate switching to induce heart failure with reduced ejection fraction

Alireza Saadatmand, Mark E. Pepin, Zihao Chen, Joshua Hartmann, Qiang Sun, Matthias Dewenter, Sumra Nazir, Harikrishnareddy Paluvai, Marco Hagenmüller, Uwe Haberkorn, Lisa Schlicker, Roberto Carlos Frias-Soler, Jens Tyedmers, Christoph Maack, Almut Schulze, Johannes Backs

The paper identifies CAMK2-NR4A1 signaling as a driver of metabolic substrate switching in heart failure with reduced ejection fraction, linking it to cardiac dysfunction through glucose utilization and lipid depletion.

bioRxiv · Oct 16, 2025 · PreprintPhysiology

Reversal of the renal hyperglycemic memory by targeting sustained tubular p21 expression

Moh’d Mohanad Al‐Dabet, Khurrum Shahzad, Ahmed Elwakiel, Alba Sulaj, Stefan Kopf, Fabian M Bock, Ihsan Gadi, Silke Zimmermann, Rajiv Rana, Shruthi Krishnan, Dheerendra Gupta, Sumra Nazir, Ronny Baber, Markus R. Scholz, Robert Geffers, , Berend Heinrich Isermann

The paper identifies p21 as a key mediator of hyperglycemic memory in diabetic kidney disease and shows that aPC signaling can reverse its effects.

bioRxiv · Jul 5, 2021 · PreprintMolecular Biology