Extracellular methylglyoxal; the passage across brain endothelial cells and the effect on barrier function
Eline Berends, Sarah Guimbal, Xiaodi Zhang, Isa Frijns, Marjo P. H. van de Waarenburg, Jean L.J.M. Scheijen, Kristiaan Wouters, Robert J. van Oostenbrugge, Britta Engelhardt, Casper G. Schalkwijk, Sébastien Foulquier
This study investigates whether methylglyoxal (MGO) crosses the blood-brain barrier (BBB) in vivo and affects BBB permeability in vitro, finding no significant MGO passage or barrier disruption.
bioRxiv · Feb 20, 2026 · PreprintNeuroscience