Casper G. Schalkwijk

This study develops a spectral flow cytometry approach to identify macrophage subpopulations in healthy and MASH livers, revealing distinct autofluorescence signatures and highlighting the importance of accurate AF correction.

This study investigates whether methylglyoxal (MGO) crosses the blood-brain barrier (BBB) in vivo and affects BBB permeability in vitro, finding no significant MGO passage or barrier disruption.

The paper maps cis- and trans-eQTLs in blood samples to infer gene regulatory networks and prioritize trait-relevant pathways.

This paper develops a dynamic biaxial pressure myograph with two-photon microscopy to study arterial biomechanics and microstructure under physiological conditions in mice.

The study compares two ex vivo setups for measuring aortic stiffness in aged mice, finding method-specific differences in stiffness parameters and smooth muscle cell effects.

This study shows increased circulating methylglyoxal in healthy mice does not cause cerebral microvascular dysfunction or cognitive impairment.

The paper develops interpretable neural networks for multi-omics data to predict smoking status, age, and LDL levels, showing improved performance and generalizability across cohorts.

The paper identifies 818 genes influencing DNA methylation in blood using genetic anchors and causal inference, revealing both transcription factors and non-DNA-binding proteins with regulatory roles.

The paper identifies 49 gene drivers of downstream transcriptional changes using population genomics data and RNA-sequencing from 3,072 individuals.

The paper identifies context-dependent eQTLs in peripheral blood RNA-seq data from Dutch individuals using a hypothesis-free approach, revealing gene expression influenced by cell type and signaling pathways.