Author

Sébastien Foulquier

Maastricht UniversityORCID 0000-0002-2523-0748Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Organism:mouse· 3 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

Robert J. van OostenbruggeiD· 4 shared Casper G. SchalkwijkiD· 2 shared Denise J. H. P. Hermes· 2 shared Eline BerendsiD· 2 shared Jean L.J.M. ScheijeniD· 2 shared Kristiaan WoutersiD· 2 shared Marjo P. H. van de Waarenburg· 2 shared Amanda J. KiliaaniD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersNeuroscience

Robert J. van OostenbruggeORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Downregulation of Trpv4 and Klf2 in brain microvessels is associated with the progression of neurovascular dysfunction and cognitive impairment in a model of heart failure with preserved ejection fraction.

Sara M.P. Lambrichts, Laura van der Taelen, Irene Pastor, Peter J. A. Leenders, Nicole J.J.E. Bitsch, Daria Majcher, Denise J. H. P. Hermes, S P Simmonds, Marcel H. M. van Herwijnen, Rick Kamps, Ellen Weltjens, Phyllis J. J. Jessen, H.P. Steinbusch, Floor Arentz, Maximilian Wiesmann, , Sébastien Foulquier

This study shows that reduced Trpv4 and Klf2 in brain microvessels correlates with neurovascular dysfunction and cognitive decline in an HFpEF rat model.

Journal of Cerebral Blood Flow & Metabolism · Jun 12, 2026Peer-reviewedNeuroscience

Extracellular methylglyoxal; the passage across brain endothelial cells and the effect on barrier function

Eline Berends, Sarah Guimbal, Xiaodi Zhang, Isa Frijns, Marjo P. H. van de Waarenburg, Jean L.J.M. Scheijen, Kristiaan Wouters, Robert J. van Oostenbrugge, Britta Engelhardt, Casper G. Schalkwijk, Sébastien Foulquier

This study investigates whether methylglyoxal (MGO) crosses the blood-brain barrier (BBB) in vivo and affects BBB permeability in vitro, finding no significant MGO passage or barrier disruption.

bioRxiv · Feb 20, 2026 · PreprintNeuroscience

Increased levels of circulating methylglyoxal have no consequence for cerebral microvascular integrity and cognitive function in young healthy mice

Eline Berends, Philippe Vangrieken, Naima Amiri, Marjo P. H. van de Waarenburg, Jean L.J.M. Scheijen, Denise J. H. P. Hermes, Kristiaan Wouters, Robert J. van Oostenbrugge, Casper G. Schalkwijk, Sébastien Foulquier

This study shows increased circulating methylglyoxal in healthy mice does not cause cerebral microvascular dysfunction or cognitive impairment.

Molecular Neurobiology · Oct 16, 2024Peer-reviewedNeuroscience

Pharmacological depletion of microglia prevents vascular cognitive impairment in Ang II-induced hypertension

Daniëlle Kerkhofs, Britt T.J. van Hagen, Irina V. Milanova, Kimberly J Schell, Helma van Essen, Erwin Wijnands, Pieter Goossens, W. Matthijs Blankesteijn, Thomas Unger, Jos Prickaerts, Erik A.L. Biessen, Robert J. van Oostenbrugge, Sébastien Foulquier

This study shows that pharmacological depletion of microglia prevents short-term memory impairment in Ang II-induced hypertension.

Theranostics · Jan 1, 2020Peer-reviewedNeuroscience