Pathogenesis of H5N1 Clade 2.3.4.4b in dry Jersey cows following intramammary inoculation shows within-host compartmentalization
Konner R. Cool, Jessie D. Trujillo, Taeyong Kwon, Gagandeep Singh, Sujan Kafle, Chester D. McDowell, Isaac Fitz, Shanmugasundaram Elango, Eu‐Lim Lyoo, Govindsamy Vediyappan, Wanting Wei, Heather M. Machkovech, Franco Matías Ferreyra, William Cody Wilson, Brittany D. Cronk, , Jüergen A. Richt
This study shows that dry Jersey cows are highly susceptible to H5N1 HPAIV, with virus dose affecting mastitis severity in udder quarters.
bioRxiv · Sep 18, 2026 · PreprintMicrobiology