Author

Isaac McKie

Max Planck Florida Institute for Neuroscience

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Abhishikta Srigiriraju· 2 shared Binbin XuiD· 2 shared Elaina RegieriD· 2 shared Isabellah Nikitah· 2 shared M. McLean BoltoniD· 2 shared Maya M. OpendakiD· 2 shared Sarah A. SterniD· 2 shared Skylar A. Anthony· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersNeuroscience

Abhishikta Srigiriraju

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4 papers

Recent·Most cited

Adversity severity shapes caregiving predictors and neural correlates of infant social behavior

Allison Su, Elaina Regier, Chloe Lim, Isaac McKie, Ben Perez-Flesler, Vishal Win, Isabellah Nikitah, Brianna C Bullock, Damaris Chacon, Lucy Sparks Mendez, Keita Fogus, Kellie L. Tamashiro, Patrese A. Robinson, Maya M. Opendak

The paper investigates how varying levels of early-life adversity affect caregiving behaviors and neural correlates of infant social behavior in mice.

bioRxiv · Sep 30, 2026 · PreprintNeuroscience

Bile acid signaling as a therapeutically tractable pathway linking early caregiving adversity to social behavior

Cesar Medina, Pragney Deme, Vishal Win, Isabellah Nikitah, Isaac McKie, Mingyuan Song, Maria Raudales, Elaina Regier, Emily Amsden, Pranali Bendale, Norman J. Haughey, Maya M. Opendak

This study identifies bile acid signaling as a pathway linking early caregiving adversity to social behavior, showing that CDCA supplementation can rescue social deficits in a rat model.

bioRxiv · Aug 22, 2026 · PreprintNeuroscience

Direct interoceptive input to the insular cortex shapes learned feeding behavior

Zhe Zhao, Binbin Xu, Skylar A. Anthony, Suganya Subramanian, Bryan Granger, Carolyn Von-Walter, Elisa Mizrachi, Dhruvum Bajpai, Paul Tyagi, Matthew Kidd, Abhishikta Srigiriraju, Isaac McKie, Zhiying Li, M. McLean Bolton, Stefano Berto, Sarah A. Stern

This study identifies leptin receptor-positive neurons in the insula that regulate feeding behavior and body weight through direct interoceptive input.

bioRxiv · May 13, 2025 · PreprintNeuroscience

INGEsT: An Open-Source Behavioral Setup for Studying Self-motivated Ingestive Behavior and Learned Operant Behavior

Zhe Zhao, Binbin Xu, Cody L. Loomis, Skylar A. Anthony, Isaac McKie, Abhishikta Srigiriraju, M. McLean Bolton, Sarah A. Stern

The paper introduces INGEsT, a behavioral setup for studying ingestive and operant behaviors, demonstrating its use in tracking neural activity during feeding and drinking tasks.

bioRxiv · Mar 10, 2024 · PreprintNeuroscience